pentobarbital will minimize the extent or impact of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; prevent use in sufferers who will be chronically making use of a solid CYP3A4 inducerIn years past, barbiturates have been a common Sectio